General Info
| Host: | Rabbit |
| Applications: | ELISA/IHC/IP/WB |
| Reactivity: | Human/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ELOVL1 (148-198) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.5 µg/µl |
| Dilution Range: | WB: 1:500ELISA: 1:10, 000IP: 1:200IHC: 1:100 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | ELOVL1 |
| Gene ID: | 64834 |
| Uniprot ID: | ELOV1_HUMAN |
| Immunogen Region: | 148-198 |
| Immunogen: | Synthetic peptide taken within amino acid region 148-198 on human Elongation of very long chain fatty acids protein 1. |
Description
| Tissue Specificity | Ubiquitous. |
| Function | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. |
| Protein Name | Elongation Of Very Long Chain Fatty Acids Protein 13-Keto Acyl-Coa Synthase Elovl1Elovl Fatty Acid Elongase 1Elovl Fa Elongase 1Very Long Chain 3-Ketoacyl-Coa Synthase 1Very Long Chain 3-Oxoacyl-Coa Synthase 1 |
| Database Links | Reactome: R-HSA-2046105Reactome: R-HSA-2046106Reactome: R-HSA-75876 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Elongation Of Very Long Chain Fatty Acids Protein 1 antibodyAnti-3-Keto Acyl-Coa Synthase Elovl1 antibodyAnti-Elovl Fatty Acid Elongase 1 antibodyAnti-Elovl Fa Elongase 1 antibodyAnti-Very Long Chain 3-Ketoacyl-Coa Synthase 1 antibodyAnti-Very Long Chain 3-Oxoacyl-Coa Synthase 1 antibodyAnti-ELOVL1 antibodyAnti-SSC1 antibodyAnti-CGI-88 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance