Anti-Cd4 antibody (Clone: GK1.5) {PE/TR}

Clonality:	Monoclonal
Clone ID:	GK1.5
Conjugation:	PE/TR
Isotype:	IgG2bk
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	Cd4
Gene ID:	12504
Uniprot ID:	CD4_MOUSE

Tissue Specificity	Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.
Post Translational Modifications	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. Phosphorylated by PKC.phosphorylation plays an important role for CD4 internalization.
Function	Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
Protein Name	T-Cell Surface Glycoprotein Cd4 T-Cell Differentiation Antigen L3t4 T-Cell Surface Antigen T4/Leu-3 Cd Antigen Cd4
Database Links	Reactome: R-MMU-1462054 Reactome: -MMU-202424 Reactome: -MMU-202427 Reactome: -MMU-202430 Reactome: -MMU-202433 Reactome: -MMU-389948 Reactome: -MMU-449836 Reactome: -MMU-8856825 Reactome: -MMU-8856828
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-T-Cell Surface Glycoprotein Cd4 antibody Anti-T-Cell Differentiation Antigen L3t4 antibody Anti-T-Cell Surface Antigen T4/Leu-3 antibody Anti-Cd Antigen Cd4 antibody Anti-Cd4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance