Anti-Cd28 antibody (Clone: 37.51) {AF647}

Clonality:	Monoclonal
Clone ID:	37.51
Conjugation:	AF647
Isotype:	IgG
Formulation:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Concentration:	0.5 mg/mL
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	Cd28
Gene ID:	12487
Uniprot ID:	CD28_MOUSE

Post Translational Modifications	Phosphorylated by LCK. Dephosphorylated by PTPN11.
Function	Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis. Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells.
Protein Name	T-Cell-Specific Surface Glycoprotein Cd28 Cd Antigen Cd28
Database Links	Reactome: R-MMU-1257604 Reactome: -MMU-389356 Reactome: -MMU-389357 Reactome: -MMU-389359 Reactome: -MMU-6811558
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-T-Cell-Specific Surface Glycoprotein Cd28 antibody Anti-Cd Antigen Cd28 antibody Anti-Cd28 antibody

Information sourced from Uniprot.org

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