Reagents and instruments for immunology, cell biology and molecular biology.

β-Amyloid 1-40, 42, Human (aa10-24) Control Peptide

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Cat# A2275-74O-100ug

Size : 100ug

Brand : US Biological

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A2275-74O β-Amyloid 1-40, 42, Human (aa10-24) Control Peptide

Clone Type

Polyclonal

Grade

Highly Purified

Applications

E WB

Crossreactivity

Ch Hu Mo Po Rb Rt Sh

Shipping Temp

Blue Ice

Storage Temp

-20°C

Goat anti-human beta Amyloid antibodies was raised using synthetic 10-24 aa of human b-1-40/42 conjugated to KLH.||Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. One of the most important and initial step involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43 aa peptides (beta amyloid1-40, 1-42, and 1-43). Polymerization of b-amyloid (Ab) and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition. Ab deposits have also been found to contain 2 additional proteins termed a-synuclein and b-synuclein. The 140 aa a-synucleins is identical with non- Ab component (NACP) of AD. The 134 aa human b-synuclein is homologous to 14kD bovine phosphoneuroprotein 14. Mutations in a-synuclein gene causing a replacement of alanine with a threonine may cause the protein to misfold. Synucleins are primarily expressed in the brain. At least 3 forms: two large (140 aa SYN-1 & 149 aa SYN-2) and a small form (SYN-3, 42 aa) are produced by alternative splicing.

Applications

Source: Human synthetic peptide|Purity: Highly purified|Concentration: 1mg/ml|Form: Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide|Specificity: Peptide sequence is found in human Beta amyloids (1-40/42/43). It is 100% conserved in human, g. porcine, porcine, sheep, rabbit and chicken. There is just 1 aa change in mouse and rat beta amyloids||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide

Purity

Highly purified

Specificity

Peptide sequence is found in human Beta amyloids (1-40/42/43). It is 100% conserved in human, g. porcine, porcine, sheep, rabbit and chicken. There is just 1 aa change in mouse and rat beta amyloids

References

Neve R et al (1992) PNAS 89, 3448; Goldgaber D et al (1987) Science 235, 877; Yankner B et al (1989) Science 245, 417; Golde T et al (1992) Science 255, 728; Wang R et al (1991) J. Biol. Chem. 266, 16960, Shigematuse K et al (1992) J Neurosci. 31, 443; kang J et al (1987) Nature 325, 733; Tanzi r et al (1987) Science 235, 880; Weidmann A et al (1989) Cell 57, 115;