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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Application

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human brain, cerebellum with SCN1A polyclonal antibody (Cat # PAB26052).
Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

  • Specifications

    Product Description

    Rabbit polyclonal antibody raised against synthetic peptide of SCN1A.

    Immunogen

    A synthetic peptide corresponding to 16 amino acids at N-terminus of human SCN1A.

    Host

    Rabbit

    Reactivity

    Chicken, Dog, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat

    Specificity

    BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SCN2A (100%), SCN3A (94%).

    Form

    Liquid

    Recommend Usage

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL)
    The optimal working dilution should be determined by the end user.

    Storage Buffer

    In PBS (0.09% sodium azide)

    Storage Instruction

    Store at 4°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.

    Note

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

  • Applications

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

    Immunohistochemical staining of human brain, cerebellum with SCN1A polyclonal antibody (Cat # PAB26052).
    Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
  • Gene Info — SCN1A

    Entrez GeneID

    6323

    Protein Accession#

    P35498

    Gene Name

    SCN1A

    Gene Alias

    FEB3, GEFSP2, HBSCI, NAC1, Nav1.1, SCN1, SMEI

    Gene Description

    sodium channel, voltage-gated, type I, alpha subunit

    Omim ID

    182389 604233 604403 607208 609634

    Gene Ontology

    Hyperlink

    Gene Summary

    The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders

    Other Designations

    febrile convulsions 3|sodium channel protein, brain I alpha subunit|sodium channel, voltage-gated, type I, alpha|sodium channel, voltage-gated, type I, alpha polypeptide

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