Rat OGDH (Oxoglutarate Dehydrogenase) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Ogdh
Gene ID:	360975
Uniprot ID:	ODO1_RAT
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	The OGDH-containing OGDHC complex is present in the brain and in the heart.
Post Translational Modifications
Function	2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC (Probable). Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (Probable). Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids. Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate. Mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.
Protein Name	2-Oxoglutarate Dehydrogenase Complex Component E1 E1o Ogdc-E1 Ogdh-E1 2-Oxoglutarate Dehydrogenase - Mitochondrial Alpha-Ketoglutarate Dehydrogenase Alpha-Kgdh-E1 Thiamine Diphosphate Thdp-Dependent 2-Oxoglutarate Dehydrogenase
Database Links	Reactome: R-RNO-389661 Reactome: -RNO-71064 Reactome: -RNO-71403
Cellular Localisation	Mitochondrion Nucleus Mainly Localizes In The Mitochondrion A Small Fraction Localizes To The Nucleus Where The 2-Oxoglutarate Dehydrogenase Complex Is Required For Histone Succinylation
Alternative ELISA Names	2-Oxoglutarate Dehydrogenase Complex Component E1 ELISA kit E1o ELISA kit Ogdc-E1 ELISA kit Ogdh-E1 ELISA kit 2-Oxoglutarate Dehydrogenase - Mitochondrial ELISA kit Alpha-Ketoglutarate Dehydrogenase ELISA kit Alpha-Kgdh-E1 ELISA kit Thiamine Diphosphate ELISA kit Thdp-Dependent 2-Oxoglutarate Dehydrogenase ELISA kit Ogdh ELISA kit Ogdhl ELISA kit
output

Information sourced from Uniprot.org

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