Nexturastat A [1403783-31-2]
Cat# HY-16699-10mg
Size : 10mg
Brand : MedChemExpress
Nexturastat A is a potent, selective HDAC6 inhibitor. Nexturastat A has inhibitory for HDAC6 with an IC50 of 5 nM. Nexturastat A can be used for the research of multiple myeloma (MM).
For research use only. We do not sell to patients.
Nexturastat A Chemical Structure
CAS No. : 1403783-31-2
This product is a controlled substance and not for sale in your territory.
Based on 3 publication(s) in Google Scholar
View All HDAC Isoform Specific Products:
Description |
Nexturastat A is a potent, selective HDAC6 inhibitor. Nexturastat A has inhibitory for HDAC6 with an IC50 of 5 nM. Nexturastat A can be used for the research of multiple myeloma (MM)[1][2]. |
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IC50 & Target[1] |
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In Vitro |
Nexturastat A (5 g) has inhibitory for HDAC6 with IC50 values of 0.005 μM[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[1]
Cell Viability Assay[2]
Apoptosis Analysis[2]
RT-PCR[2]
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In Vivo |
Nexturastat A (NexA) (every two days, 20 days) inhibits tumor growth in murine xenograft models of MM[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
341.40 |
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Formula |
C19H23N3O3 |
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CAS No. |
1403783-31-2 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C(NO)C1=CC=C(CN(CCCC)C(NC2=CC=CC=C2)=O)C=C1 |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : ≥ 56 mg/mL (164.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.03% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.9291 mL | 14.6456 mL | 29.2912 mL | 73.2279 mL |
5 mM | 0.5858 mL | 2.9291 mL | 5.8582 mL | 14.6456 mL | |
10 mM | 0.2929 mL | 1.4646 mL | 2.9291 mL | 7.3228 mL | |
15 mM | 0.1953 mL | 0.9764 mL | 1.9527 mL | 4.8819 mL | |
20 mM | 0.1465 mL | 0.7323 mL | 1.4646 mL | 3.6614 mL | |
25 mM | 0.1172 mL | 0.5858 mL | 1.1716 mL | 2.9291 mL | |
30 mM | 0.0976 mL | 0.4882 mL | 0.9764 mL | 2.4409 mL | |
40 mM | 0.0732 mL | 0.3661 mL | 0.7323 mL | 1.8307 mL | |
50 mM | 0.0586 mL | 0.2929 mL | 0.5858 mL | 1.4646 mL | |
60 mM | 0.0488 mL | 0.2441 mL | 0.4882 mL | 1.2205 mL | |
80 mM | 0.0366 mL | 0.1831 mL | 0.3661 mL | 0.9153 mL | |
100 mM | 0.0293 mL | 0.1465 mL | 0.2929 mL | 0.7323 mL |
Nexturastat A Related Classifications
- Cell Cycle/DNA Damage Epigenetics
- HDAC