General Info
Applications: | ELISA |
Reactivity: | Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Sensitivity: | 0.053ng/mL |
Detection Limit: | 0.156-10ng/mL |
Short Description: | This CACNa1B Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
Assay Time: | 4.5 hrs |
Information
Gene Symbol: | Cacna1b |
Gene ID: | 12287 |
Uniprot ID: | CAC1B_MOUSE |
Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
Description
Tissue Specificity | Widespread expression throughout the brain. Highest levels in pyramidal cell layers C1, C2 and C3 of the hippocampus, in the dentate gyrus, in the cortex layers 2 et 4, in the subiculum and the habenula. |
Post Translational Modifications | Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK. |
Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals. |
Protein Name | Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1bBrain Calcium Channel IiiBiiiCalcium Channel - L Type - Alpha-1 Polypeptide Isoform 5Voltage-Gated Calcium Channel Subunit Alpha Cav2.2 |
Database Links | Reactome: R-MMU-112308 |
Cellular Localisation | MembraneMulti-Pass Membrane Protein |
Alternative ELISA Names | Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1b ELISA kitBrain Calcium Channel Iii ELISA kitBiii ELISA kitCalcium Channel - L Type - Alpha-1 Polypeptide Isoform 5 ELISA kitVoltage-Gated Calcium Channel Subunit Alpha Cav2.2 ELISA kitCacna1b ELISA kitCach5 ELISA kitCacnl1a5 ELISA kitCchn1a ELISA kit |
output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance