ML349 [890819-86-0]
Cat# HY-100737-1ml
Size : 10mM/1mL
Brand : MedChemExpress
ML349 is a potent and specific acyl protein thioesterase 2(APT2)/lysophospholipase 2 (LYPLA2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM.
For research use only. We do not sell to patients.
ML349 Chemical Structure
CAS No. : 890819-86-0
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
View All Phospholipase Isoform Specific Products:
Description |
ML349 is a potent and specific acyl protein thioesterase 2(APT2)/lysophospholipase 2 (LYPLA2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM[1][2]. |
IC50 & Target |
Ki: 120 nM (APT-2)[1] |
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In Vitro |
ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis? of? >10000 and 120±20 nM, respectively[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
454.56 |
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Formula |
C23H22N2O4S2 |
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CAS No. |
890819-86-0 |
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Appearance |
Solid |
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Color |
White to yellow |
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SMILES |
COC1=CC=C(N2CCN(C(C3=CC4=C(C(C=CC=C5)=C5S(C4)(=O)=O)S3)=O)CC2)C=C1 |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 20 mg/mL (44.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : < 0.1 mg/mL (insoluble) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation | |||||||||||||
References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.1999 mL | 10.9996 mL | 21.9993 mL | 54.9982 mL |
5 mM | 0.4400 mL | 2.1999 mL | 4.3999 mL | 10.9996 mL | |
10 mM | 0.2200 mL | 1.1000 mL | 2.1999 mL | 5.4998 mL | |
15 mM | 0.1467 mL | 0.7333 mL | 1.4666 mL | 3.6665 mL | |
20 mM | 0.1100 mL | 0.5500 mL | 1.1000 mL | 2.7499 mL | |
25 mM | 0.0880 mL | 0.4400 mL | 0.8800 mL | 2.1999 mL | |
30 mM | 0.0733 mL | 0.3667 mL | 0.7333 mL | 1.8333 mL | |
40 mM | 0.0550 mL | 0.2750 mL | 0.5500 mL | 1.3750 mL |
ML349 Related Classifications
- Metabolic Enzyme/Protease
- Phospholipase