Diatrizoic acid [117-96-4]
Cat# HY-B0926-1ml
Size : 10mM/1mL
Brand : MedChemExpress
Diatrizoic acid (Diatrizoate) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Diatrizoic acid induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium.
For research use only. We do not sell to patients.
Diatrizoic acid Chemical Structure
CAS No. : 117-96-4
This product is a controlled substance and not for sale in your territory.
Description |
Diatrizoic acid (Diatrizoate) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Diatrizoic acid induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium[1][2]. |
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In Vitro |
HK-2 cells are exposed to 0-30 mg I/mL Diatrizoic acid (Diatrizoate) or vehicle for 2-24 h. MTT and trypan blue exclusion indicate a decrease in mitochondrial and cell viability within 2 and 24 h, respectively[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Diatrizoic acid is an iodinated radiocontrast agent. Histological examination of rat lung tissue shows no acute toxicity or inflammation after insufflation of Diatrizoic acid nanoparticle agglomerates. Diatrizoic acid nanoparticle agglomerates offers a promising radiocontrast agent for safe and effective lung visualization[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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Molecular Weight |
613.91 |
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Formula |
C11H9I3N2O4 |
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CAS No. |
117-96-4 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C(O)C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (162.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.86% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 1.6289 mL | 8.1445 mL | 16.2890 mL | 40.7226 mL |
5 mM | 0.3258 mL | 1.6289 mL | 3.2578 mL | 8.1445 mL | |
10 mM | 0.1629 mL | 0.8145 mL | 1.6289 mL | 4.0723 mL | |
15 mM | 0.1086 mL | 0.5430 mL | 1.0859 mL | 2.7148 mL | |
20 mM | 0.0814 mL | 0.4072 mL | 0.8145 mL | 2.0361 mL | |
25 mM | 0.0652 mL | 0.3258 mL | 0.6516 mL | 1.6289 mL | |
30 mM | 0.0543 mL | 0.2715 mL | 0.5430 mL | 1.3574 mL | |
40 mM | 0.0407 mL | 0.2036 mL | 0.4072 mL | 1.0181 mL | |
50 mM | 0.0326 mL | 0.1629 mL | 0.3258 mL | 0.8145 mL | |
60 mM | 0.0271 mL | 0.1357 mL | 0.2715 mL | 0.6787 mL | |
80 mM | 0.0204 mL | 0.1018 mL | 0.2036 mL | 0.5090 mL | |
100 mM | 0.0163 mL | 0.0814 mL | 0.1629 mL | 0.4072 mL |
Diatrizoic acid Related Classifications
- Apoptosis
- Apoptosis