DAPT [208255-80-5]
Cat# HY-13027-5mg
Size : 5mg
Brand : MedChemExpress
DAPT (GSI-IX) est un inhibiteur de la γ-sécrétase puissant et oralement actif avec des IC50 de 115 nM et 200 nM pour un total < b>amyloïde-β (Aβ) et Aβ42, respectivement. DAPT inhibe l'activation de la signalisation Notch 1 et induit la différenciation cellulaire. DAPT induit également l'autophagie et l'apoptose. DAPT a une activité de neuroprotection et a le potentiel pour les maladies auto-immunes et lymphoprolifératives, les maladies dégénératives et le traitement du cancer.
DAPT (GSI-IX) ist ein potenter und oral wirksamer γ-secretase mit einem IC50s von 115 nM und 200 nM für Gesamtamyloid-β (Aβ) und Aβ42. DAPT hemmt die Aktivierung des Notch 1-Signals und induziert die Zelldifferenzierung. DAPT induziert auch autophagy und apoptosis. DAPT besitzt eine Neuroprotektionsaktivität und hat das Potenzial für die Behandlung von Autoimmun- und lymphoproliferativen Krankheiten, degenerativen Erkrankungen und Krebs.
DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment.
For research use only. We do not sell to patients.
DAPT Chemical Structure
CAS No. : 208255-80-5
This product is a controlled substance and not for sale in your territory.
Based on 110 publication(s) in Google Scholar
Other Forms of DAPT:
- DAPT (GMP) Get quote
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DAPT purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2022 Oct 19;246:114183. [Abstract]
- Detection of cell viability after treatment with different concentrations of DAPT (5 μM, 10 μM, 15 μM, 20 μM; for 24 h).
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DAPT purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2022 Oct 19;246:114183. [Abstract]
- DAPT treatment enhances the protein expression of Bax and decreases the expression of Bcl2. And the expression of cleaved-caspase3 is upregulated after DAPT treatment (10 μM; for 24 h).
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DAPT purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2019 Mar;14(3):452-461. [Abstract]
- Western blot assay for Hes1 (left) and Hes5 (right) protein expression in the right prefrontal cortex of cerebral I/R mice following DAPT treatment.
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DAPT purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Nov;107:1370-1376. [Abstract]
- ECa109 and EC9706 cells are treated with concentrations of GSI-DAPT (0, 10 and 20 μM) for 48 h. The expressions of Notch3, DTX1 and Hes1 are investigated by Western blotting.
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DAPT purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Nov;107:1370-1376. [Abstract]
- ECa109 and EC9706 cells are treated with concentrations of GSI-DAPT (0, 10 and 20 μM) for 48 h. The expressions of LSD1 and H3K4me2 are investigated by Western blotting.
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DAPT purchased from MedChemExpress. Usage Cited in: Int J Cancer. 2018 Aug 1;143(3):645-656. [Abstract]
- Evaluation of expression change of Notch downstream under the androgen-deprived condition with or without the treatment of DAPT by western blot assay.
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DAPT purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2018 Mar;233(3):2225-2237. [Abstract]
- DAPTprevents Nicd splitting from Notch1 and has been recognized as a Notch1 pathway inhibitor. Treatment with DAPT also inhibits the expression of Col IV and FN, resembling the effect of Notch1 siRNA.
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DAPT purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2018 Nov 8;12:3847-3854. [Abstract]
- Western anslysis of protein analysis of NOX2, NICD, Hes1, Hes5 in the treatment of TBI, TBI+vehicle, TBI+DAPT and TBI+DPI, respectively.
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DAPT purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2018 Oct 26;120(2):1903-1915. [Abstract]
- The distribution of aggrecan is increased in the DAPT group.
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DAPT purchased from MedChemExpress. Usage Cited in: PLoS One. 2018 Feb 15;13(2):e0193037. [Abstract]
- After DAPT treatment, the protein levels of Notch, Hes1 and Hes5 are downregulated in severe injury group. After DAPT treatment, the protein levels of Bcl-2 are upregulated while those of Bax, caspase-3 and caspase-9 are downregulated.
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DAPT purchased from MedChemExpress. Usage Cited in: World J Gastroenterol. 2017 Apr 7;23(13):2330-2336. [Abstract]
- Notch γ-secretase inhibitor attenuates notch and transforming growth factor-β signaling pathways in peripheral blood mononuclear cells of liver fibrosis rats. Western blot analysis of protein expression of Notch1, Hes1, Hes5, TGF-β and Smad3 and quantification in PBMCs (2 × 106) from rats treated with DAPT or DMSO for 24 h.
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DAPT purchased from MedChemExpress. Usage Cited in: Department Medicine. Yale University. 2016 Jan.
- Treatment with DAPT does not markedly alter expression of p27Kip1 in bulk or CD133- cells, but dramatically enhances its expression in CD133+ cells.