General Info
| Host: | Mouse |
| Applications: | IHC-F/FC/ELISA/WB |
| Reactivity: | Human/Guinea Pig/Mouse/Rhesus |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Tumor Necrosis factor Alpha is suitable for use in Immunohistochemistry, Flow Cytometry, ELISA and Western Blot research applications. |
| Clonality: | Monoclonal |
| Clone ID: | 52B83 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | PBS with 0.1% BSA and 0.02% sodium azide |
| Concentration: | 100 ug/mL |
| Storage Instruction: | Store at 2-8°C upon receipt. |
Information
Description
| Background | The monoclonal antibody 52B83 reacts with tumor necrosis factor alpha (TNF-alpha). TNF-alpha is a homotrimeric 17 kDa protein, that interacts with either one of the two types of TNF-receptors, termed I and II, leading to receptor cross-linking and signal transduction. The receptors differ strongly in their intra-cellular signaling pathways. TNF-alpha was originally described as a highly cytotoxic cytokine for tumor cells, it causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Furthermore,-TNF-alpha is found to be a central mediator in many inflammatory and immunological processes. It can be induced by various products of micro-organisms and by various cytokines leading to expression of a wide variety of-cytokines. The pro-inflammatory properties of-TNF-alpha play a central role in several auto-immune diseases such as rheumatoid arthritis and inhibition by neutralizing molecules have been shown to be beneficial in patients. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance