General Info
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-TBX3 (310-480) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | TBX3 |
| Gene ID: | 6926 |
| Uniprot ID: | TBX3_HUMAN |
| Immunogen Region: | 310-480 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 310-480 of human TBX3 (NP_057653.3). |
| Immunogen Sequence: | RREKRKQLTLQSMRVFDERH KKENGTSDESSSEQAAFNCF AQASSPAASTVGTSNLKDLC PSEGESDAEAESKEEHGPEA CDAAKISTTTSEEPCRDKGS PAVKAHLFAAERPRDSGRLD KASPDSRHSPATISSSTRGL GAEERRSPVREGTAPAKVEE ARALPGKEAFA |
Description
| Tissue Specificity | Widely expressed. |
| Function | Transcriptional repressor involved in developmental processes. Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes. Probably plays a role in limb pattern formation. Required for mammary placode induction, and maintenance of the mammary buds during development. Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes.acting redundantly with TBX2. Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme.perhaps acting downstream of SHH, BMP and TGFbeta signaling. Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear. Acts as a negative regulator of PML function in cellular senescence. |
| Protein Name | T-Box Transcription Factor Tbx3T-Box Protein 3 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-T-Box Transcription Factor Tbx3 antibodyAnti-T-Box Protein 3 antibodyAnti-TBX3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance