General Info
| Host: | Rabbit |
| Applications: | ELISA/IP/WB |
| Reactivity: | Bovine/Human/Mouse/Rat/Sheep |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-AQP2 (200-250) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.50-0.62 µg/µl |
| Dilution Range: | WB: 1:500 ELISA: 1:10, 000 IP: 1:200 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | Aqp2 |
| Gene ID: | 25386 |
| Uniprot ID: | AQP2_RAT |
| Immunogen Region: | 200-250 |
| Immunogen: | Synthetic peptide taken within amino acid region 200-250 on human Aquaporin 2 protein. |
Description
| Tissue Specificity | Detected in kidney, in cortical and the medullary collecting tubules (at protein level). Detected in kidney medulla and cortex. |
| Post Translational Modifications | Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent. N-glycosylated. |
| Function | Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. Could also be permeable to glycerol. |
| Protein Name | Aquaporin-2 Aqp-2 Adh Water Channel Aquaporin-Cd Aqp-Cd Collecting Duct Water Channel Protein Wch-Cd Water Channel Protein For Renal Collecting Duct |
| Database Links | Reactome: R-RNO-432040 Reactome: -RNO-432047 |
| Cellular Localisation | Apical Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Cell Membrane Cytoplasmic Vesicle Membrane Golgi Apparatus Trans-Golgi Network Membrane Shuttles From Vesicles To The Apical Membrane Vasopressin-Regulated Phosphorylation Is Required For Translocation To The Apical Cell Membrane Plekha8/Fapp2 Is Required To Transport Aqp2 From The Tgn To Sites Where Aqp2 Is Phosphorylated |
| Alternative Antibody Names | Anti-Aquaporin-2 antibody Anti-Aqp-2 antibody Anti-Adh Water Channel antibody Anti-Aquaporin-Cd antibody Anti-Aqp-Cd antibody Anti-Collecting Duct Water Channel Protein antibody Anti-Wch-Cd antibody Anti-Water Channel Protein For Renal Collecting Duct antibody Anti-Aqp2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance