AKT1/2/3 Polyclonal Antibody, APC-Cy7 Conjugated
Cat# bs-0115R-APC-Cy7
Size : 100ul
Brand : Bioss
AKT1/2/3 Polyclonal Antibody, APC-Cy7 Conjugated
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-0115R-APC-Cy7 |
Product Name | AKT1/2/3 Polyclonal Antibody, APC-Cy7 Conjugated |
Applications | WB, FCM, IF(IHC-P), IF(IHC-F), IF(ICC) |
Reactivity | Human, Mouse, Rat, Bovine, Pig, Others |
Predicted Reactivity | Dog, Cow, Sheep, Chicken |
Specifications | |
Conjugation | APC-Cy7 |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human AKT1 |
Immunogen Range | 401-479/479 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target | |
Gene ID | 207 |
Swiss Prot | P31749 |
Subcellular location | Cytoplasm, Nucleus, Cell membrane |
Synonyms | AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; Protein kinase B; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha; AKT1; RAC-gamma serine/threonine-protein kinase; Protein kinase Akt-3; Protein kinase B gamma; PKB gamma; RAC-PK-gamma; STK-2; PKBG |
Background | AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation. |
Application Dilution | |
WB | 1:300-5000 |
FCM | 1:20-100 |
IF(IHC-P) | 1:50-200 |
IF(IHC-F) | 1:50-200 |
IF(ICC) | 1:50-200 |