Tocilizumab [375823-41-9]
Cat# T9911-25mg
Size : 25mg
Brand : TargetMol
Tocilizumab
Contact us for more batch information
Concentration:20.1 mg/mL
Purity:99.50%
Resource Download
COA
Tocilizumab
Catalog No. T9911Cas No. 375823-41-9
Tocilizumab (anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. Pack Size | |
---|---|
1 mg | |
2 mg | |
5 mg | |
10 mg | |
25 mg | |
50 mg | |
100 mg |
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
Description | Tocilizumab (anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor |
Cell Research | Objective: To validate that IL-6 signaling is essential for TAM (tumor-associated macrophages)-enhanced CSC (cancer stem cells) function. Concentrations: 5 μg/ml. Incubation Time: 72 h. Method: For co-culture experiments, 12-well Transwell chambers were used with 2×105 HepG2 or Hep3B cells seeded in the lower chamber one day before co-culture and either 5×105 or 1×106 TAMs added in the upper chamber. Tocilizumab or human IgG antibody were added in indicated experiments to selected wells. After 24 to 72 hours, HCC cells and CD14+ TAM cells were collected separately for analysis. Cells:HepG2 cell lines, TAMs isolated from HCCs (hepatocellular carcinoma) |
Molecular Weight | 148 kDa |
Cas No. | 375823-41-9 |
Storage | store at -20°C | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
Dose Conversion
You can also refer to dose conversion for different animals. More
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
COVID-19IL-6RAnti-Human IL6R, Humanized Antibodyrheumatoidrespiratory failureantibodyInterleukin Relatedcoronavirus diseasearthritisinhibitTocilizumabdyspnoeaNeutralizingInhibitor
Related Tags: buy Tocilizumab | purchase Tocilizumab | Tocilizumab cost | order Tocilizumab | Tocilizumab chemical structure | Tocilizumab molecular weight