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Sarcosine [107-97-1]

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Cat# T6975-500mg

Size : 500mg

Brand : TargetMol

Sarcosine

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COA HNMR HPLC

Sarcosine

Catalog No. T6975Cas No. 107-97-1

Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.

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Pack Size
500 mg
1 g
5 g
10 g

Product Introduction

Bioactivity

Description	Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
In vitro	Sarcosine is a GlyR agonist in addition to being a GlyT1 inhibitor and NMDAR co-agonist, but it is less potent than glycine as a GlyR agonist and is not a full agonist[1]. The viability of the sarcosine-treated cells is significantly reduced[4].
In vivo	Sarcosine has weak anticonvulsant properties[2]. It ameliorates (prepulse inhibition)PPI deficits in mGluR5 knockout mice[3].
Cell Research	Immediately after the cells grow to 50-60% confluence, the cultivation medium is replaced by fresh medium to synchronise cell growth. Cells are cultivated for 24 h under these conditions. Subsequently, the culture medium is supplemented with sarcosine (N-methylglycine) diluted to a final concentration 10, 150, 250, 500, 1,000 and 1,500 μM. Treatment is carried out for 0, 6, 12, 24 and 72 h, and samples are collected at these strictly defined time points.(Only for Reference)
Alias	Sarcosinic acid, Methylaminoacetic acid, Sarcosin, Methylglycine, N-Methylaminoacetic acid, N-methylglycine

Chemical Properties

Molecular Weight	89.09
Formula	C3H7NO2
Cas No.	107-97-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: Insoluble

H2O: 10 mM

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	11.2246 mL	56.1230 mL	112.2460 mL	561.2302 mL
5 mM	2.2449 mL	11.2246 mL	22.4492 mL	112.2460 mL
10 mM	1.1225 mL	5.6123 mL	11.2246 mL	56.1230 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

inhibitdysfunctionschizophreniaEndogenous MetaboliteInhibitorSarcosinecognitivedepressionGlyTGlycine transporters