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> Remdesivir de(ethylbutyl 2-aminopropanoate) [2607871-93-0]

Remdesivir de(ethylbutyl 2-aminopropanoate) [2607871-93-0]

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Cat# HY-145949

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Brand : MedChemExpress


Remdesivir de(ethylbutyl 2-aminopropanoate) is an impurity of Remdesivir. Remdesivir, a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.

For research use only. We do not sell to patients.

Remdesivir de(ethylbutyl 2-aminopropanoate) Chemical Structure

Remdesivir de(ethylbutyl 2-aminopropanoate) Chemical Structure

CAS No. : 2607871-93-0

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Description

Remdesivir de(ethylbutyl 2-aminopropanoate) is an impurity of Remdesivir. Remdesivir, a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2].

Molecular Weight

447.34

Formula

C18H18N5O7P
CAS No.

2607871-93-0
SMILES

N#C[C@@]([C@@H]([C@@H]1O)O)(C2=CC=C3N2N=CN=C3N)O[C@@H]1CO[P](OC4=CC=CC=C4)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References

  • [1]. Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2):e00221-18.  [Content Brief]

    [2]. Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.  [Content Brief]

  • [1]. Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2):e00221-18.

    [2]. Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.

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Remdesivir de(ethylbutyl 2-aminopropanoate) Related Classifications

  • Metabolic Enzyme/Protease
  • Drug Metabolite

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Remdesivir de(ethylbutyl 2-aminopropanoate)2607871-93-0Drug MetaboliteInhibitorinhibitorinhibit