General Info
| Applications: | ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.224ng/mL |
| Detection Limit: | 0.625-40ng/mL |
| Short Description: | This RYR1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
Information
| Gene Symbol: | Ryr1Uniprot ID=RYR1_RAT" |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
Description
| Tissue Specificity | Detected in skeletal muscle (at protein level). Detected in myometrium smooth muscle. |
| Post Translational Modifications | Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2840 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2840. Activated by reversible S-nitrosylation. Repeated very high-level exercise increases S-nitrosylation. |
| Function | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis. |
| Protein Name | Ryanodine Receptor 1Ryr-1Ryr1Skeletal Muscle Calcium Release ChannelSkeletal Muscle Ryanodine ReceptorSkeletal Muscle-Type Ryanodine ReceptorType 1 Ryanodine Receptor |
| Database Links | |
| Cellular Localisation | Sarcoplasmic Reticulum MembraneMulti-Pass Membrane ProteinThe Number Of Predicted Transmembrane Domains Varies Between OrthologsBoth N-Terminus And C-Terminus Are Cytoplasmic |
| Alternative ELISA Names | Ryanodine Receptor 1 ELISA kitRyr-1 ELISA kitRyr1 ELISA kitSkeletal Muscle Calcium Release Channel ELISA kitSkeletal Muscle Ryanodine Receptor ELISA kitSkeletal Muscle-Type Ryanodine Receptor ELISA kitType 1 Ryanodine Receptor ELISA kitRyr1 ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance