Rat ADAMTS4 (A Disintegrin And Metalloproteinase With Thrombospondin 4) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Adamts4
Gene ID:	66015
Uniprot ID:	ATS4_RAT
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Brain specific.
Post Translational Modifications	The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion.
Function	Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Protein Name	A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Adam-Ts 4 Adam-Ts4 Adamts-4 Aggrecanase-1
Database Links	Reactome: R-RNO-1474228 Reactome: -RNO-5173214
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative ELISA Names	A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 ELISA kit Adam-Ts 4 ELISA kit Adam-Ts4 ELISA kit Adamts-4 ELISA kit Aggrecanase-1 ELISA kit Adamts4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance