Polymyxin B nonapeptide [86408-36-8]
Cat# HY-106783-50mg
Size : 50mg
Brand : MedChemExpress
Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes.
For research use only. We do not sell to patients.
Custom Peptide Synthesis
Polymyxin B nonapeptide Chemical Structure
CAS No. : 86408-36-8
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of Polymyxin B nonapeptide:
- Polymyxin B nonapeptide TFA In-stock
View All Antibiotic Isoform Specific Products:
Description |
Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[1][2][3]. |
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In Vitro |
Polymyxin B nonapeptide (2-32 μg/mL, 24 h) has a synergistic effect with Azithromycin (HY-17506)[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
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In Vivo |
Polymyxin B nonapeptide (1.5, 3.0 mg/kg intravenously for 29 days) does not exhibit neuromuscular blocking, neurotoxic, or nephrotoxic effects in rats as observed with polymyxin B sulfate[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
963.13 |
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Formula |
C43H74N14O11 |
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CAS No. |
86408-36-8 |
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Appearance |
Solid |
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Color |
White to off-white |
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Sequence |
Thr-{Dab}-{Dab}-{Dab}-d-Phe-Leu-{Dab}-{Dab}-Thr (Lactam: Dab3-Thr9) |
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Sequence Shortening |
T-{Dab}-{Dab}-{Dab}-d-FL-{Dab}-{Dab}-T (Lactam: Dab3-Thr9) |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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Solvent & Solubility |
In Vitro:
H2O : ≥ 100 mg/mL (103.83 mM) DMSO : 16.67 mg/mL (17.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation |
Purity: 99.82% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO / H2O | 1 mM | 1.0383 mL | 5.1914 mL | 10.3828 mL | 25.9570 mL |
5 mM | 0.2077 mL | 1.0383 mL | 2.0766 mL | 5.1914 mL | |
10 mM | 0.1038 mL | 0.5191 mL | 1.0383 mL | 2.5957 mL | |
15 mM | 0.0692 mL | 0.3461 mL | 0.6922 mL | 1.7305 mL | |
H2O | 20 mM | 0.0519 mL | 0.2596 mL | 0.5191 mL | 1.2979 mL |
25 mM | 0.0415 mL | 0.2077 mL | 0.4153 mL | 1.0383 mL | |
30 mM | 0.0346 mL | 0.1730 mL | 0.3461 mL | 0.8652 mL | |
40 mM | 0.0260 mL | 0.1298 mL | 0.2596 mL | 0.6489 mL | |
50 mM | 0.0208 mL | 0.1038 mL | 0.2077 mL | 0.5191 mL | |
60 mM | 0.0173 mL | 0.0865 mL | 0.1730 mL | 0.4326 mL | |
80 mM | 0.0130 mL | 0.0649 mL | 0.1298 mL | 0.3245 mL | |
100 mM | 0.0104 mL | 0.0519 mL | 0.1038 mL | 0.2596 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Polymyxin B nonapeptide Related Classifications
- Infection
- Anti-infection
- Bacterial Antibiotic