In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Background
Human alloantisera specific for either the Bak' or Bakb allele have been shown to react exclusively with the heavy chain of membrane glycoprotein (GP) Ilb.
GPllb is composed of a 125 Kd heavy chain that is disulfide-linked to a 23 Kd light chain. Hydropathicity analysis of the cDNA sequence indicates that GPllb is anchored to the platelet through a single transmembrane domain located within 20 amino acids of the C-terminus of the light chain.
The GPllb-IIa complex is a Ca2+-dependent heterodimer that, on activated platelets, can bind one of the four different adhesive proteins. (i.e. fibrinogen, fibronectin, von Willebrand factor, or vitronectin ).
Ref:
1. Bray PF, Rosa J-P, Lingappa VR, Kan YW, McEver RP, Shuman MA: Biogenesis of the platelet receptor for fibrinogen: Evidence for separate precursors for glycoproteins Ilb and IIIa. Proc Natl Acad Sci USA 83:1480,1986
2. Silver SM, McDonough MM, Vilaire G, Bennett JS: The in vitro synthesis of polypeptides for the platelet membrane glycoproteins IIb and IIIa. Blood 69:1031, 1987.
3. Phillips DR, Charo IF, Parise LV, Fitzgerald LA : The platelet membrane glycoproteins IIb-IIIa co,plex. Blood 71:831-843, 1988
Product Citation
1. Feng Wang, Kai-Rui Feng, et al. "Identification of novel STAT3 inhibitors bearing 2-acetyl-7-phenylamino benzofuran scaffold for antitumour study." Bioorg Med Chem. 2020 Oct 22;28(24):115822. PMID: 33126089