Linezolid [165800-03-3]
Cat# HY-10394-100mg
Size : 100mg
Brand : MedChemExpress
Linezolid (PNU-100766) is the first member of the class of oxazolidinone synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. Linezolid is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics.
For research use only. We do not sell to patients.
Linezolid Chemical Structure
CAS No. : 165800-03-3
This product is a controlled substance and not for sale in your territory.
Based on 29 publication(s) in Google Scholar
Other Forms of Linezolid:
- Linezolid-d3 In-stock
- PNU-100766-d8 Get quote
View All Antibiotic Isoform Specific Products:
Description |
Linezolid (PNU-100766) is the first member of the class of oxazolidinone synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. Linezolid is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics[1][2][3]. |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IC50 & Target |
|
||||||||||||
In Vitro |
Linezolid (PNU-100766) prevents the synthesis of bacterial protein via binding to rRNA on both the 30S and 50S ribosomal subunits[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||
Clinical Trial |
|
||||||||||||
Molecular Weight |
337.35 |
||||||||||||
Formula |
C16H20FN3O4 |
||||||||||||
CAS No. |
165800-03-3 |
||||||||||||
Appearance |
Solid |
||||||||||||
Color |
White to off-white |
||||||||||||
SMILES |
O=C(O[C@H]1CNC(C)=O)N(C1)C2=CC(F)=C(N3CCOCC3)C=C2 |
||||||||||||
Shipping | Room temperature in continental US; may vary elsewhere. |
||||||||||||
Storage |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
||||||||||||
Solvent & Solubility |
In Vitro:
DMSO : ≥ 100 mg/mL (296.43 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
|
||||||||||||
Purity & Documentation |
Purity: 99.95% |
||||||||||||
References |
|
Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
---|
DMSO | 1 mM | 2.9643 mL | 14.8214 mL | 29.6428 mL | 74.1070 mL |
5 mM | 0.5929 mL | 2.9643 mL | 5.9286 mL | 14.8214 mL | |
10 mM | 0.2964 mL | 1.4821 mL | 2.9643 mL | 7.4107 mL | |
15 mM | 0.1976 mL | 0.9881 mL | 1.9762 mL | 4.9405 mL | |
20 mM | 0.1482 mL | 0.7411 mL | 1.4821 mL | 3.7054 mL | |
25 mM | 0.1186 mL | 0.5929 mL | 1.1857 mL | 2.9643 mL | |
30 mM | 0.0988 mL | 0.4940 mL | 0.9881 mL | 2.4702 mL | |
40 mM | 0.0741 mL | 0.3705 mL | 0.7411 mL | 1.8527 mL | |
50 mM | 0.0593 mL | 0.2964 mL | 0.5929 mL | 1.4821 mL | |
60 mM | 0.0494 mL | 0.2470 mL | 0.4940 mL | 1.2351 mL | |
80 mM | 0.0371 mL | 0.1853 mL | 0.3705 mL | 0.9263 mL | |
100 mM | 0.0296 mL | 0.1482 mL | 0.2964 mL | 0.7411 mL |
Linezolid Related Classifications
- Anti-infection
- Bacterial Antibiotic