G-418 (disulfate) [108321-42-2]
Cat# HY-17561-1g
Size : 1g
Brand : MedChemExpress
G-418 disulfate (Geneticin sulfate), is an aminoglycoside antibiotic, inhibits protein synthesis in eukaryotes and prokaryotes. G-418 disulfate is commonly used as a selective agent for eukaryotic cells.
For research use only. We do not sell to patients.
G-418 disulfate Chemical Structure
CAS No. : 108321-42-2
This product is a controlled substance and not for sale in your territory.
Based on 32 publication(s) in Google Scholar
Other Forms of G-418 disulfate:
- G-418 Get quote
View All Antibiotic Isoform Specific Products:
Description |
G-418 disulfate (Geneticin sulfate), is an aminoglycoside antibiotic, inhibits protein synthesis in eukaryotes and prokaryotes. G-418 disulfate is commonly used as a selective agent for eukaryotic cells[1]. |
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IC50 & Target |
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In Vitro |
G418 sulfate, an aminoglycoside neomycin analogue, interferes with protein synthesis and has been used extensively for selection of mammalian cell lines that possess neomycin resistance (NR). The neomycin resistance (neo) gene is frequently used in eukaryotic vectors as a dominant selectable gene. G418 can be covalently bound to asialoorosomucoid (AsOR) to form a conjugate for hepatocyte-specific targeting and toxicity[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
692.71 |
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Formula |
C20H44N4O18S2 |
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CAS No. |
108321-42-2 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=S(O)(O)=O.O[C@@H]([C@@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)N)(11)O[C@]2(11)[C@H](O)C)[C@H]([C@@H](C[C@@H]1N)N)O[C@](OC[C@](C)(O)[C@@H]3NC)(11)[C@@H]3O.O=S(O)(O)=O |
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Structure Classification |
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Initial Source |
Micromonospora rhodorangea |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
4°C, stored under nitrogen, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture) |
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Solvent & Solubility |
In Vitro:
H2O : 125 mg/mL (180.45 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation |
Purity: 98.26% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O | 1 mM | 1.4436 mL | 7.2180 mL | 14.4361 mL | 36.0901 mL |
5 mM | 0.2887 mL | 1.4436 mL | 2.8872 mL | 7.2180 mL | |
10 mM | 0.1444 mL | 0.7218 mL | 1.4436 mL | 3.6090 mL | |
15 mM | 0.0962 mL | 0.4812 mL | 0.9624 mL | 2.4060 mL | |
20 mM | 0.0722 mL | 0.3609 mL | 0.7218 mL | 1.8045 mL | |
25 mM | 0.0577 mL | 0.2887 mL | 0.5774 mL | 1.4436 mL | |
30 mM | 0.0481 mL | 0.2406 mL | 0.4812 mL | 1.2030 mL | |
40 mM | 0.0361 mL | 0.1805 mL | 0.3609 mL | 0.9023 mL | |
50 mM | 0.0289 mL | 0.1444 mL | 0.2887 mL | 0.7218 mL | |
60 mM | 0.0241 mL | 0.1203 mL | 0.2406 mL | 0.6015 mL | |
80 mM | 0.0180 mL | 0.0902 mL | 0.1805 mL | 0.4511 mL | |
100 mM | 0.0144 mL | 0.0722 mL | 0.1444 mL | 0.3609 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
G-418 disulfate Related Classifications
- Infection
- Anti-infection
- Bacterial Antibiotic