FR054 [35954-65-5]
Cat# HY-124909A-10mg
Size : 10mg
Brand : MedChemExpress
FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect.
For research use only. We do not sell to patients.
FR054 Chemical Structure
CAS No. : 35954-65-5
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of FR054:
- (6R)-FR054 In-stock
Description |
FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect[1]. |
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In Vitro |
FR054 (0.5-1 mM, 24-48 h) induces an early proliferation arrest followed by a marked cell death increase in breast cancer cells and induces apoptosis. The effect of FR054 occurs through PGM3 inhibition instead of other off-target effects[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
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In Vivo |
FR054 (1000?mg/kg, ip) suppresses cancer growth in MDA-MB-231 xenograft mice[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Molecular Weight |
329.30 |
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Formula |
C14H19NO8 |
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CAS No. |
35954-65-5 |
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Appearance |
Oil |
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Color |
Colorless to light yellow |
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SMILES |
CC(O[C@@H]1[C@]2(07)[C@](OC(C)=N2)(07)O[C@@H]([C@H]1OC(C)=O)COC(C)=O)=O |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (303.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: ≥97.0% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 3.0367 mL | 15.1837 mL | 30.3674 mL | 75.9186 mL |
5 mM | 0.6073 mL | 3.0367 mL | 6.0735 mL | 15.1837 mL | |
10 mM | 0.3037 mL | 1.5184 mL | 3.0367 mL | 7.5919 mL | |
15 mM | 0.2024 mL | 1.0122 mL | 2.0245 mL | 5.0612 mL | |
20 mM | 0.1518 mL | 0.7592 mL | 1.5184 mL | 3.7959 mL | |
25 mM | 0.1215 mL | 0.6073 mL | 1.2147 mL | 3.0367 mL | |
30 mM | 0.1012 mL | 0.5061 mL | 1.0122 mL | 2.5306 mL | |
40 mM | 0.0759 mL | 0.3796 mL | 0.7592 mL | 1.8980 mL | |
50 mM | 0.0607 mL | 0.3037 mL | 0.6073 mL | 1.5184 mL | |
60 mM | 0.0506 mL | 0.2531 mL | 0.5061 mL | 1.2653 mL | |
80 mM | 0.0380 mL | 0.1898 mL | 0.3796 mL | 0.9490 mL | |
100 mM | 0.0304 mL | 0.1518 mL | 0.3037 mL | 0.7592 mL |
FR054 Related Classifications
- Others
- Others