CR2 monoclonal antibody, clone LT21 (FITC)
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- More Files
- Specifications
Product Description
Mouse monoclonal antibody raised against native CR2.
Immunogen
Native purified CR2 from human B-lymphoblastoid cell line IM9.CR2.
Host
Mouse
Theoretical MW (kDa)
145
Reactivity
Bovine, Human, Pig
Specificity
This antibody reacts with CD21 (CR2), a 145 KDa transmembrane glycoprotein (complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells, some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature B cells.
Form
Liquid
Conjugation
FITC
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Flow Cytometry
- Gene Info — CR2
Entrez GeneID
1380Gene Name
CR2
Gene Alias
C3DR, CD21, SLEB9
Gene Description
complement component (3d/Epstein Barr virus) receptor 2
Gene Ontology
HyperlinkGene Summary
Complement component receptor-2 (CR2) is the membrane protein on B lymphocytes to which the Epstein-Barr virus (EBV) binds during infection of these cells. See also CR1 (MIM 120620). Yefenof et al. (1976) [PubMed 181330] found complete overlapping of EBV receptors and C3 (MIM 120700) receptors on human B lymphocytes.[supplied by OMIM
Other Designations
OTTHUMP00000034421|OTTHUMP00000034447
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Antiphospholipid syndrome patients display reduced titers of soluble CD21 in their sera irrespective of circulating anti-beta2-glycoprotein-I autoantibodies.
Singh A, Blank M, Shoenfeld Y, Illges H.
Rheumatology International 2008 May; 28(7):661.
- Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis.
Zabel MD, Heikenwalder M, Prinz M, Arrighi I, Schwarz P, Kranich J, von Teichman A, Haas KM, Zeller N, Tedder TF, Weis JH, Aguzzi A.
Journal of Immunology 2007 Nov; 179(9):6144.
Application：Flow Cyt, Mouse, Mouse peripheral blood cells.
- Cross-reactive anti-human monoclonal antibodies as a tool for B-cell identification in dogs and pigs.
Faldyna M, Samankova P, Leva L, Cerny J, Oujezdska J, Rehakova Z, Sinkora J.
Veterinary Immunology and Immunopathology 2007 Sep; 119(1-2):56.
Application：Flow cyt, Dog, Swine, Peripheral blood leukocytes.
- Antiphospholipid syndrome patients display reduced titers of soluble CD21 in their sera irrespective of circulating anti-beta2-glycoprotein-I autoantibodies.