Camostat (mesylate) [59721-29-8]
Cat# HY-13512-100mg
Size : 100mg
Brand : MedChemExpress
Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase.
For research use only. We do not sell to patients.
Camostat mesylate Chemical Structure
CAS No. : 59721-29-8
This product is a controlled substance and not for sale in your territory.
Based on 28 publication(s) in Google Scholar
Description |
Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase[1][2][3]. |
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In Vitro |
Camostat mesylate (Camostat mesilate) inhibits both monocyte chemoattractant protein-1 (MCP-1) and TNF-α production from monocytes, and proliferation and MCP-1 production from PSCs[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Camostat mesilate (30 mg/kg; p.o.; twice a day for 9 days) blocks the spread and pathogenesis of SARS-CoV in a pathogenic mouse model[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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Molecular Weight |
494.52 |
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Formula |
C21H26N4O8S |
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CAS No. |
59721-29-8 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C(OCC(N(C)C)=O)CC1=CC=C(OC(C2=CC=C(NC(N)=N)C=C2)=O)C=C1.CS(=O)(O)=O |
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Initial Source |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
4°C, sealed storage, away from moisture *In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture) |
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Solvent & Solubility |
In Vitro:
DMSO : 125 mg/mL (252.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : ≥ 50 mg/mL (101.11 mM) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation |
Purity: 99.93% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 2.0222 mL | 10.1108 mL | 20.2216 mL | 50.5541 mL |
5 mM | 0.4044 mL | 2.0222 mL | 4.0443 mL | 10.1108 mL | |
10 mM | 0.2022 mL | 1.0111 mL | 2.0222 mL | 5.0554 mL | |
15 mM | 0.1348 mL | 0.6741 mL | 1.3481 mL | 3.3703 mL | |
20 mM | 0.1011 mL | 0.5055 mL | 1.0111 mL | 2.5277 mL | |
25 mM | 0.0809 mL | 0.4044 mL | 0.8089 mL | 2.0222 mL | |
30 mM | 0.0674 mL | 0.3370 mL | 0.6741 mL | 1.6851 mL | |
40 mM | 0.0506 mL | 0.2528 mL | 0.5055 mL | 1.2639 mL | |
50 mM | 0.0404 mL | 0.2022 mL | 0.4044 mL | 1.0111 mL | |
60 mM | 0.0337 mL | 0.1685 mL | 0.3370 mL | 0.8426 mL | |
80 mM | 0.0253 mL | 0.1264 mL | 0.2528 mL | 0.6319 mL | |
100 mM | 0.0202 mL | 0.1011 mL | 0.2022 mL | 0.5055 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Camostat mesylate Related Classifications
- Metabolic Enzyme/Protease Anti-infection
- Ser/Thr Protease SARS-CoV