Anti-SNF8 antibody (200-250) {FITC}

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.5-1.5 µg/µl
Dilution Range:	WB: 1:2, 500-1:5, 000 ELISA: 1:50, 000 IP: 1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	SNF8
Gene ID:	11267
Uniprot ID:	SNF8_HUMAN
Immunogen Region:	200-250
Immunogen:	Synthetic peptide taken within amino acid region 200-250 on human Vacuolar-sorting Protein SNF8 protein.

Function	Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan.
Protein Name	Vacuolar-Sorting Protein Snf8 Ell-Associated Protein Of 30 Kda Escrt-Ii Complex Subunit Vps22 Hvps22
Database Links	Reactome: R-HSA-917729 Reactome: R-HSA-9610379
Cellular Localisation	Cytoplasm Endosome Membrane Nucleus Late Endosome Membrane Recruited To The Endosome Membrane To Participate In Vesicle Formation
Alternative Antibody Names	Anti-Vacuolar-Sorting Protein Snf8 antibody Anti-Ell-Associated Protein Of 30 Kda antibody Anti-Escrt-Ii Complex Subunit Vps22 antibody Anti-Hvps22 antibody Anti-SNF8 antibody Anti-EAP30 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance