General Info
| Host: | Rabbit |
| Applications: | CM/ELISA/ICC/IF/IHC/IP/WB |
| Reactivity: | Chicken/Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-PDE5A is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.55 µg/µl |
| Dilution Range: | WB: 1:500-1:1, 000DB: 1:10, 000ELISA: 1:10, 000IP: 1:250IHC: 1:250ICC: 1:250IF: 1:250CFM: 1:250 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | PDE5A |
| Gene ID: | 8654 |
| Uniprot ID: | PDE5A_HUMAN |
| Immunogen: | Recombinant protein common to all PDE5A variants corresponding to human PDE5A protein. |
Description
| Tissue Specificity | Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung. |
| Post Translational Modifications | Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Phosphorylation by PRKG1 leads to its activation. |
| Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. |
| Protein Name | Cgmp-Specific 3' -5'-Cyclic PhosphodiesteraseCgmp-Binding Cgmp-Specific PhosphodiesteraseCgb-Pde |
| Database Links | Reactome: R-HSA-418457Reactome: R-HSA-445355Reactome: R-HSA-9013422 |
| Alternative Antibody Names | Anti-Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase antibodyAnti-Cgmp-Binding Cgmp-Specific Phosphodiesterase antibodyAnti-Cgb-Pde antibodyAnti-PDE5A antibodyAnti-PDE5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance