Anti-IL4 antibody (Clone: MP4-25D2) {PE/TR}

Clonality:	Monoclonal
Clone ID:	MP4-25D2
Conjugation:	PE/TR
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	IL4
Gene ID:	3565
Uniprot ID:	IL4_HUMAN

Function	Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1. Regulates also the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. In addition, plays a critical role in higher functions of the normal brain, such as memory and learning. Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is expressed also on nonhematopoietic cells. Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6.
Protein Name	Interleukin-4 Il-4 B-Cell Stimulatory Factor 1 Bsf-1 Binetrakin Lymphocyte Stimulatory Factor 1 Pitrakinra
Database Links	Reactome: R-HSA-6785807 Reactome: R-HSA-9012546
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Interleukin-4 antibody Anti-Il-4 antibody Anti-B-Cell Stimulatory Factor 1 antibody Anti-Bsf-1 antibody Anti-Binetrakin antibody Anti-Lymphocyte Stimulatory Factor 1 antibody Anti-Pitrakinra antibody Anti-IL4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance