General Info
| Host: | Mouse |
| Applications: | IP/WB/IHC-P |
| Reactivity: | Rat/Cow/Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Csk binding protein is suitable for use in Immunoprecipitation, Western Blot and Immunohistochemistry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | PAG-C1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Formulation: | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Concentration: | 1 mg/mL |
| Storage Instruction: | Store at 2-8°C upon receipt. |
Information
| Gene Symbol: | PAG1 |
| Gene ID: | 55824 |
| Uniprot ID: | PHAG1_HUMAN |
| Immunogen: | C-terminal peptide (last 15 amino acids) of human Csk binding protein coupled to KLH. |
Description
| Tissue Specificity | Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level). |
| Post Translational Modifications | Palmitoylated. Phosphorylated by FYN on Tyr-317 in resting T-cells.which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation.which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN. |
| Function | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. |
| Protein Name | Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1Csk-Binding ProteinTransmembrane Adapter Protein PagTransmembrane Phosphoprotein Cbp |
| Database Links | Reactome: R-HSA-180292Reactome: R-HSA-202427 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane ProteinPresent In Lipid Rafts |
| Alternative Antibody Names | Anti-Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1 antibodyAnti-Csk-Binding Protein antibodyAnti-Transmembrane Adapter Protein Pag antibodyAnti-Transmembrane Phosphoprotein Cbp antibodyAnti-PAG1 antibodyAnti-CBP antibodyAnti-PAG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance