Anti-APH1B antibody (235-257)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.6 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	APH1B
Gene ID:	83464
Uniprot ID:	APH1B_HUMAN
Immunogen Region:	235-257
Specificity:	Does not cross react to other component of gamma secretase complex nor with other proteins.
Immunogen:	Synthetic peptide taken within amino acid region 235-257 of Human Presenilin stabilizing protein.

Tissue Specificity	Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain.
Function	Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
Protein Name	Gamma-Secretase Subunit Aph-1b Aph-1b Aph-1beta Presenilin-Stabilization Factor-Like
Database Links	Reactome: R-HSA-1251985 Reactome: R-HSA-193692 Reactome: R-HSA-205043 Reactome: R-HSA-2122948 Reactome: R-HSA-2644606 Reactome: R-HSA-2894862 Reactome: R-HSA-2979096 Reactome: R-HSA-3928665 Reactome: R-HSA-9013507 Reactome: R-HSA-9013700 Reactome: R-HSA-9017802 Reactome: R-HSA-977225
Cellular Localisation	Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-Gamma-Secretase Subunit Aph-1b antibody Anti-Aph-1b antibody Anti-Aph-1beta antibody Anti-Presenilin-Stabilization Factor-Like antibody Anti-APH1B antibody Anti-PSFL antibody Anti-UNQ688 antibody Anti-PRO1328 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance