6-Dodecanoyl-N,N-dimethyl-2-naphthylamine is a fluorescent membrane probe used in phospholipid multilamellar aggregates which distinguishes between phase transitions, phase fluctuations and the coexistence of phase domains. Studies indicate that the bulky and highly hydrated polar head groups of glycosphingolipids interact well with 6-Dodecanoyl-N,N-dimethyl-2-naphthylamine. The fluorescence is derived from the naphthalene moiety, in which a small dipole moment exists due to a partial charge separation between the 2-dimethylamino and the 6-carbonyl residues. This fluorescent tag is ideal to study dipolar relaxation because this compound emits different light depending on the environment it is in. For instance, 6-Dodecanoyl-N,N-dimethyl-2-naphthylamine emits red light in a polar solvent and blue light in an apolar solvent.||Synonyms:|1-[6-(Dimethylamino)-2-naphthalenyl]-1-dodecanone; 6-Lauroyl-2-(dimethylamino)naphthalene; N,N-Dimethyl-6-dodecanoyl-2-naphthylamine; Laurdan||CAS No:|74515-25-6||Molecular Formula:|C₂₄H₃₅NO||Molecular Weight:|353.54||Appearance:|White to off-white crystalline solid||Purity:|≥98%||Solubility:|Laurdan is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of laurdan in ethanol is approximately 1mg/ml and approximately 30mg/ml in DMSO and DMF. Laurdan is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, laurdan should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Laurdan has a solubility of approximately 0.5mg/ml in a 1:1 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.||Storage and Stability:|Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.