General Info
| Host: | Mouse |
| Applications: | FC |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-T-lymphocyte activation antigen CD86 is suitable for use in Flow Cytometry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | BU63 |
| Conjugation: | AF647 |
| Isotype: | IgG1k |
| Formulation: | PBS with 0.05% Proclin300, 1% BSA |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Information
| Gene Symbol: | CD86 |
| Gene ID: | 942 |
| Uniprot ID: | CD86_HUMAN |
Description
| Tissue Specificity | Expressed by activated B-lymphocytes and monocytes. |
| Post Translational Modifications | Polyubiquitinated.which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. |
| Function | Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. Isoform 2: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B. |
| Protein Name | T-Lymphocyte Activation Antigen Cd86Activation B7-2 AntigenB70Bu63Ctla-4 Counter-Receptor B7.2Fun-1Cd Antigen Cd86 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-389356Reactome: R-HSA-389357Reactome: R-HSA-389359Reactome: R-HSA-389513Reactome: R-HSA-6783783Reactome: R-HSA-6811558 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Lymphocyte Activation Antigen Cd86 antibodyAnti-Activation B7-2 Antigen antibodyAnti-B70 antibodyAnti-Bu63 antibodyAnti-Ctla-4 Counter-Receptor B7.2 antibodyAnti-Fun-1 antibodyAnti-Cd Antigen Cd86 antibodyAnti-CD86 antibodyAnti-CD28LG2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance