Reagents and instruments for immunology, cell biology and molecular biology.

Anti-CD18/ITGB2 antibody (Clone: TS1/18.1.2.11) {AF647}

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Cat# NB-22-60921-200

Size : 200Tests

Brand : Neo Biotech

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Human peripheral blood lymphocytes were stained with Anti-CD18 antibody (filled gray histogram). Unstained lymphocytes (empty black histogram) were used as control.

General Info

Host:	Mouse
Applications:	FC
Reactivity:	Human
Note:	FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Integrin beta-2 is suitable for use in Flow Cytometry research applications.

Clonality:	Monoclonal
Clone ID:	TS1/18.1.2.11
Conjugation:	AF647
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Information

Gene Symbol:	ITGB2
Gene ID:	3689
Uniprot ID:	ITB2_HUMAN

Description

Tissue Specificity	Leukocytes. Expressed in neutrophils (at protein level).
Post Translational Modifications	Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.
Function	Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils.
Protein Name	Integrin Beta-2 Cell Surface Adhesion Glycoproteins Lfa-1/Cr3/P150 -95 Subunit Beta Complement Receptor C3 Subunit Beta Cd Antigen Cd18
Database Links	Reactome: R-HSA-166016 Reactome: R-HSA-198933 Reactome: R-HSA-202733 Reactome: R-HSA-216083 Reactome: R-HSA-6785807 Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft
Alternative Antibody Names	Anti-Integrin Beta-2 antibody Anti-Cell Surface Adhesion Glycoproteins Lfa-1/Cr3/P150 -95 Subunit Beta antibody Anti-Complement Receptor C3 Subunit Beta antibody Anti-Cd Antigen Cd18 antibody Anti-ITGB2 antibody Anti-CD18 antibody Anti-MFI7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance