Tadalafil [171596-29-5]
Cat# HY-90009A-100mg
Size : 100mg
Brand : MedChemExpress
Tadalafil (IC-351) is a PDE5 inhibitor with an IC50 value of 1.8 nM.
For research use only. We do not sell to patients.
Tadalafil Chemical Structure
CAS No. : 171596-29-5
This product is a controlled substance and not for sale in your territory.
Based on 5 publication(s) in Google Scholar
Other Forms of Tadalafil:
- Nortadalafil In-stock
- cis-Tadalafil In-stock
- ent-Tadalafil In-stock
- cis-ent-Tadalafil In-stock
- Tadalafil-d3 In-stock
View All Phosphodiesterase (PDE) Isoform Specific Products:
Description |
Tadalafil (IC-351) is a PDE5 inhibitor with an IC50 value of 1.8 nM. |
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IC50 & Target |
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In Vitro |
Biochemical potencies (affinities) of these compounds for PDE5 determined by IC(50), K(D) (isotherm), K(D) (dissociation rate), and K(D) ((1/2) EC(50)), respectively, were the following: sildenafil (3.7 +/- 1.4, 4.8 +/- 0.80, 3.7 +/- 0.29, and 11.7 +/- 0.70 nM), tadalafil (1.8 +/- 0.40, 2.4 +/- 0.60, 1.9 +/- 0.37, and 2.7 +/- 0.25 nM); and vardenafil (0.091 +/- 0.031, 0.38 +/- 0.07, 0.27 +/- 0.01, and 0.42 +/- 0.10 nM). Thus, absolute potency values were similar for each inhibitor, and relative potencies were vardenafil >> tadalafil > sildenafil[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
The Tadalafil-treated group showed enhanced erectile function (intracavernosal pressure/mean arterial pressure) at 0.3, 0.5, 1, 3, and 5 Hz compared with diabetic group values at the respective frequencies that approached control values[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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Molecular Weight |
389.40 |
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Formula |
C22H19N3O4 |
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CAS No. |
171596-29-5 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C([C@@]1(23)CC2=C([C@@H](C3=CC=C(OCO4)C4=C3)N15)NC6=C2C=CC=C6)N(C)CC5=O |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : ≥ 52 mg/mL (133.54 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation | |||||||||||||
References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.5681 mL | 12.8403 mL | 25.6805 mL | 64.2013 mL |
5 mM | 0.5136 mL | 2.5681 mL | 5.1361 mL | 12.8403 mL | |
10 mM | 0.2568 mL | 1.2840 mL | 2.5681 mL | 6.4201 mL | |
15 mM | 0.1712 mL | 0.8560 mL | 1.7120 mL | 4.2801 mL | |
20 mM | 0.1284 mL | 0.6420 mL | 1.2840 mL | 3.2101 mL | |
25 mM | 0.1027 mL | 0.5136 mL | 1.0272 mL | 2.5681 mL | |
30 mM | 0.0856 mL | 0.4280 mL | 0.8560 mL | 2.1400 mL | |
40 mM | 0.0642 mL | 0.3210 mL | 0.6420 mL | 1.6050 mL | |
50 mM | 0.0514 mL | 0.2568 mL | 0.5136 mL | 1.2840 mL | |
60 mM | 0.0428 mL | 0.2140 mL | 0.4280 mL | 1.0700 mL | |
80 mM | 0.0321 mL | 0.1605 mL | 0.3210 mL | 0.8025 mL | |
100 mM | 0.0257 mL | 0.1284 mL | 0.2568 mL | 0.6420 mL |
Tadalafil Related Classifications
- Metabolic Enzyme/Protease Apoptosis
- Phosphodiesterase (PDE) Apoptosis