Ribavirin [36791-04-5]
Cat# HY-B0434-100mg
Size : 100mg
Brand : MedChemExpress
Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
For research use only. We do not sell to patients.
Ribavirin Chemical Structure
CAS No. : 36791-04-5
This product is a controlled substance and not for sale in your territory.
Based on 32 publication(s) in Google Scholar
Other Forms of Ribavirin:
- Ribavirin-13C5 In-stock
- Ribavirin (GMP) Get quote
- Ribavirin-15N, d2 Get quote
View All Antibiotic Isoform Specific Products:
Description |
Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities. |
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In Vitro |
Treatment of LPS-stimulated microglia with 5, 10 and 20 μM Ribavirin (ICN-1229) induces reduction of NO2 levels for 43% (p<0.05), 53% (p<0.05) and 59% (p<0.05), respectively. Ribavirin (ICN-1229) (10 mM) insignificantly decreases the cell surface area in non-stimulated culture, but significantly reduces cell surface area (by 32%, p<0.05) in LPS-stimulated microglia[3]. Ribavirin (ICN-1229) is active against DENV, with an EC50 of 3 μM in A549 cells, and combination of CM-10-18 with Ribavirin (ICN-1229) demonstrates a clear enhancement in the reduction of virus replication[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
ALT, AST activities and bilirubin levels are significantly loared by administration of JAT in combination with interferon and Ribavirin (ICN-1229) (p<0.01). JAT, interferon or ribavirin alone with CCl4, livers appear to exhibit some liver protection against CCl4 as evident by the presence of normal hepatic cords, absence of necrosis and lesser fatty infiltration. Groups treated with JAT, Peg-interferon and Ribavirin (ICN-1229) separately or in combination shows reduction in the expression of TGF- β and Bax. In the group treated by triple combination of interferon, Ribavirin (ICN-1229), and JAT, the expression level of p53 is markedly reduced[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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Molecular Weight |
244.20 |
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Formula |
C8H12N4O5 |
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CAS No. |
36791-04-5 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O[C@H]1[C@@H](O)[C@H](N2N=C(C(N)=O)N=C2)O[C@@H]1CO |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
H2O : 100 mg/mL (409.50 mM; Need ultrasonic) DMSO : 100 mg/mL (409.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation |
Purity: 99.80% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 4.0950 mL | 20.4750 mL | 40.9500 mL | 102.3751 mL |
5 mM | 0.8190 mL | 4.0950 mL | 8.1900 mL | 20.4750 mL | |
10 mM | 0.4095 mL | 2.0475 mL | 4.0950 mL | 10.2375 mL | |
15 mM | 0.2730 mL | 1.3650 mL | 2.7300 mL | 6.8250 mL | |
20 mM | 0.2048 mL | 1.0238 mL | 2.0475 mL | 5.1188 mL | |
25 mM | 0.1638 mL | 0.8190 mL | 1.6380 mL | 4.0950 mL | |
30 mM | 0.1365 mL | 0.6825 mL | 1.3650 mL | 3.4125 mL | |
40 mM | 0.1024 mL | 0.5119 mL | 1.0238 mL | 2.5594 mL | |
50 mM | 0.0819 mL | 0.4095 mL | 0.8190 mL | 2.0475 mL | |
60 mM | 0.0683 mL | 0.3413 mL | 0.6825 mL | 1.7063 mL | |
80 mM | 0.0512 mL | 0.2559 mL | 0.5119 mL | 1.2797 mL | |
100 mM | 0.0410 mL | 0.2048 mL | 0.4095 mL | 1.0238 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Ribavirin Related Classifications
- Anti-infection
- HCV RSV Orthopoxvirus Antibiotic