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Mouse Monoclonal Anti-ETS1 / (Marker of Tumor Metastasis) [Clone ETS1/1282]
Cat# NB-36-00158-P1ABX
Size : 100ug
Brand : Neo Biotech
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Printable Datasheet
ETS1 (Marker of Tumor Metastasis) Antibody [ETS1/1801]
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SDS-PAGE Analysis of Purified ETS1 Mouse Monoclonal Antibody (ETS1/1801). Confirmation of Integrity and Purity of Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using ETS1 Mouse Monoclonal Antibody (ETS1/1801) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.
Summary
ETS1 proto-oncogene is an important transcription factor that plays a role in cell proliferation and differentiation. ETS1 is related to the growth of carcinoma cells by its regulation of the transcription of matrix metalloproteinases and urokinase-type plasminogen activator.The processes of tumor invasion and metastasis depend on the increased proteolytic activity of the invading tumor cells that may involve matrix metalloproteinases, cathepsins B and D and plasminogen activator in the metastatic cascade. ETS1 is preferentially expressed in lymphoid cells, where it is essential for the maintenance of the normal pool of resting T and B cells.ETS1 expression level and distribution are differentially controlled in resting, activated and apoptotic lymphocytes.
Product Properties & Targets
Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA
Species Reactivity
Human
Research Areas
Cardiovascular, Hypoxia, Angiogenesis, Endothelial Cell Marker, Nuclear Marker, Ovarian Cancer
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Cytoplasm, Nucleus
Gene Name
ETS1
Positive Control
HepG2 and HeLa cells. Tonsil, Kidney and Lymphoma., Pancreas, Skin
Immunogen
Recombinant human ETS1 fragment (around aa137-230) (exact sequence is proprietary)
Alternate Names
Protein C-ets-1, p54, Avian erythroblastosis virus E26 (v ets) oncogene homolog 1; ETS1; EWSR2; p54; v-ets erythroblastosis virus E26 oncogene homolog 1
Functions
- Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
Key References
- Gaspar Kitange, et al. Immunohistochemical expression of Ets-1 transcription factor and the urokinase-type plasminogen activator is correlated with the malignant and invasive potential in meningiomas. Cancer 89 (11), 2292-2300, 2000.
PubMed Links
- https://pubmed.ncbi.nlm.nih.gov/3060801/
- https://pubmed.ncbi.nlm.nih.gov/2847145/
- https://pubmed.ncbi.nlm.nih.gov/19377509/
- https://pubmed.ncbi.nlm.nih.gov/17974005/
- https://pubmed.ncbi.nlm.nih.gov/16554811/
- https://pubmed.ncbi.nlm.nih.gov/15489334/
- https://pubmed.ncbi.nlm.nih.gov/1614856/
- https://pubmed.ncbi.nlm.nih.gov/8231246/
- https://pubmed.ncbi.nlm.nih.gov/2997781/
- https://pubmed.ncbi.nlm.nih.gov/9333025/
- https://pubmed.ncbi.nlm.nih.gov/10698492/
- https://pubmed.ncbi.nlm.nih.gov/11909962/
- https://pubmed.ncbi.nlm.nih.gov/15247905/
- https://pubmed.ncbi.nlm.nih.gov/15592455/
- https://pubmed.ncbi.nlm.nih.gov/15592518/
- https://pubmed.ncbi.nlm.nih.gov/19690332/
- https://pubmed.ncbi.nlm.nih.gov/19608861/
- https://pubmed.ncbi.nlm.nih.gov/20378371/
- https://pubmed.ncbi.nlm.nih.gov/23186163/
- https://pubmed.ncbi.nlm.nih.gov/25755297/
- https://pubmed.ncbi.nlm.nih.gov/28112733/
- https://pubmed.ncbi.nlm.nih.gov/8521493/
- https://pubmed.ncbi.nlm.nih.gov/18566588/
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
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