General Info
| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Dopamine Receptor D4 Blocking Peptide for STJ500717 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | Drd4 |
| Gene ID: | 13491 |
| Uniprot ID: | DRD4_MOUSE |
| Specificity: | This blocking peptide is recommended for use in combination with Dopamine Receptor D4 antibody, STJ500717 |
| Immunogen: | Synthetic peptide corresponding to unique sequence on Dopamine Receptor D4 protein. |
Description
| Tissue Specificity | Detected in olfactory bulb, hypothalamus, olfactory tubercle, brainstem and striatum. |
| Post Translational Modifications | Palmitoylated. Palmitoylation of the C-terminal Cys is important for normal expression at the cell membrane. |
| Function | Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs. Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells. |
| Peptide Name | D(4 Dopamine ReceptorD(2c Dopamine ReceptorDopamine D4 Receptor |
| Database Links | Reactome: R-MMU-390651Reactome: -MMU-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | D(4 Dopamine Receptor proteinD(2c Dopamine Receptor proteinDopamine D4 Receptor proteinDrd4 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance