Capecitabine [154361-50-9]
Cat# HY-B0016-1g
Size : 1g
Brand : MedChemExpress
Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.
For research use only. We do not sell to patients.
Capecitabine Chemical Structure
CAS No. : 154361-50-9
This product is a controlled substance and not for sale in your territory.
Based on 19 publication(s) in Google Scholar
Other Forms of Capecitabine:
- Capecitabine-d11 In-stock
Description |
Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase. |
IC50 & Target |
DNA/RNA Synthesis[1] |
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In Vitro |
Capecitabine is an anti-cancer chemotherapy drug. It is classified as an antimetabolite. Capecitabine is converted into 5′-deoxy-5-fluorocytidine (5′DFCR), 5′-deoxy-5-fluorouridine (5′DFUR) and 5-FU by carboxylesterases (CES1 and 2), cytidine deaminase (CDD), and thymidine phosphorylase (TP), in both liver and tumour. Capecitabine induces a significant cytotoxic effect in vitro only at high concentrations. Mean IC50 values vary from 860 μM in COLO205 cells to 6000 μM in HCT8 cells[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
A pharmacokinetic/pharmacodynamic study is carried out in mice bearing HCT 116 xenografts receiving 0.52 and 2.1 mmol/kg/d of Capecitabine by oral gavage. Capecitabine administered at 0.52 mmol/kg/day induces partial control of HCT 116 xenografts tumour growth: growth rate =7.5±0.5 on day 21. Capecitabine 2.1 mmol/kg/day achieves complete control of tumor growth during the treatment period: growth rate =1±0.2 on day 21[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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Molecular Weight |
359.35 |
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Formula |
C15H22FN3O6 |
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CAS No. |
154361-50-9 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O[C@H]1[C@@H](O)[C@H](N2C=C(C(NC(OCCCCC)=O)=NC2=O)F)O[C@@H]1C |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 250 mg/mL (695.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : ≥ 33.33 mg/mL (92.75 mM) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation |
Purity: 99.99% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 2.7828 mL | 13.9140 mL | 27.8280 mL | 69.5701 mL |
5 mM | 0.5566 mL | 2.7828 mL | 5.5656 mL | 13.9140 mL | |
10 mM | 0.2783 mL | 1.3914 mL | 2.7828 mL | 6.9570 mL | |
15 mM | 0.1855 mL | 0.9276 mL | 1.8552 mL | 4.6380 mL | |
20 mM | 0.1391 mL | 0.6957 mL | 1.3914 mL | 3.4785 mL | |
25 mM | 0.1113 mL | 0.5566 mL | 1.1131 mL | 2.7828 mL | |
30 mM | 0.0928 mL | 0.4638 mL | 0.9276 mL | 2.3190 mL | |
40 mM | 0.0696 mL | 0.3479 mL | 0.6957 mL | 1.7393 mL | |
50 mM | 0.0557 mL | 0.2783 mL | 0.5566 mL | 1.3914 mL | |
60 mM | 0.0464 mL | 0.2319 mL | 0.4638 mL | 1.1595 mL | |
80 mM | 0.0348 mL | 0.1739 mL | 0.3479 mL | 0.8696 mL | |
DMSO | 100 mM | 0.0278 mL | 0.1391 mL | 0.2783 mL | 0.6957 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Capecitabine Related Classifications
- Cell Cycle/DNA Damage Apoptosis
- DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis