Bedaquiline [843663-66-1]
Cat# T2585-50mg
Size : 50mg
Brand : TargetMol
Bedaquiline
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Purity:99.8%
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COA HNMR HPLC
Bedaquiline
Catalog No. T2585Cas No. 843663-66-1
Bedaquiline (R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. Pack Size | ||
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1 mL x 10 mM (in DMSO) | In Stock |
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
Description | Bedaquiline (R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis. |
In vitro | Bedaquiline inhibits TDR M. tuberculosis strains with MIC values between 0.125 and 0.5 mg/L[1]. It shows the highest activity against Mycobacterium avium among slowly growing mycobacteria (SGM), with MIC50 and MIC90 values of 0.03 and 16 mg/L. Among rapidly growing mycobacteria (RGM), it is more effective against Mycobacterium abscessus subsp. abscessus (M. abscessus) and Mycobacterium abscessus subsp. massiliense (M. massiliense) than Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L. Bedaquiline also exhibits moderate in vitro activity against NTM species[2] and excellent in vitro activity against Mycobacterium tuberculosis, including multidrug-resistant strains[3]. |
Alias | R207910, TMC207 |
Molecular Weight | 555.5 |
Formula | C32H31BrN2O2 |
Cas No. | 843663-66-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 5.56 mg/mL (10 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSO
main solution, add 300 μLPEG300
mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O
mix well and clarify
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
TMC 207BacterialAntibioticTMC-207BedaquilineR 207910R-207910Inhibitorinhibit
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