General Info
Host: | Rabbit |
Applications: | WB/IHC/IF |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-TIMP2 (50-150) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | TIMP2 |
Gene ID: | 7077 |
Uniprot ID: | TIMP2_HUMAN |
Immunogen Region: | 50-150 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TIMP2 (NP_003237.2). |
Immunogen Sequence: | KGPDPSSPAFRIEDANLIPP VPDDKFQDLVDAVRAEKGFL LLASLRQMKKTRGTLLALER KDHSGQVFSVVSNGKAGTLD LSLTVQGKQHVVSVEEALLA T |
Description
Post Translational Modifications | The activity of TIMP2 is dependent on the presence of disulfide bonds. |
Function | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. |
Protein Name | Metalloproteinase Inhibitor 2Csc-21kTissue Inhibitor Of Metalloproteinases 2Timp-2 |
Database Links | Reactome: R-HSA-1592389Reactome: R-HSA-6798695 |
Cellular Localisation | Secreted |
Alternative Antibody Names | Anti-Metalloproteinase Inhibitor 2 antibodyAnti-Csc-21k antibodyAnti-Tissue Inhibitor Of Metalloproteinases 2 antibodyAnti-Timp-2 antibodyAnti-TIMP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance