Anti-PSEN1 antibody (417-467)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	1.00-1.25 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:150 IHC: 1:50-1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	PSEN1
Gene ID:	5663
Uniprot ID:	PSN1_HUMAN
Immunogen Region:	417-467
Immunogen:	Synthetic peptide taken within amino acid region 417-467 on human Presnelin-1 protein.

Tissue Specificity	Detected in azurophile granules in neutrophils and in platelet cytoplasmic granules (at protein level). Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes.
Post Translational Modifications	Heterogeneous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of approximately 35 and 20 kDa, respectively. During apoptosis, the C-terminal fragment (CTF) is further cleaved by caspase-3 to produce the fragment, PS1-CTF12. After endoproteolysis, the C-terminal fragment (CTF) is phosphorylated on serine residues by PKA and/or PKC. Phosphorylation on Ser-346 inhibits endoproteolysis.
Function	Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1.this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling. Required for normal embryonic brain and skeleton development, and for normal angiogenesis. Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis. Involved in the regulation of neurite outgrowth. Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression.
Protein Name	Presenilin-1 Ps-1 Protein S182 Cleaved Into - Presenilin-1 Ntf Subunit - Presenilin-1 Ctf Subunit - Presenilin-1 Ctf12 Ps1-Ctf12
Database Links	Reactome: R-HSA-1251985 Reactome: R-HSA-1474228 Reactome: R-HSA-193692 Reactome: R-HSA-205043 Reactome: R-HSA-2122948 Reactome: R-HSA-2644606 Reactome: R-HSA-2894862 Reactome: R-HSA-2979096 Reactome: R-HSA-3928665 Reactome: R-HSA-6798695 Reactome: R-HSA-9013507 Reactome: R-HSA-9013700 Reactome: R-HSA-9017802
Cellular Localisation	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Golgi Apparatus Membrane Cytoplasmic Granule Cell Membrane Cell Projection Growth Cone Early Endosome Early Endosome Membrane Neuron Projection Axon Synapse Translocates With Bound Notch1 From The Endoplasmic Reticulum And/Or Golgi To The Cell Surface Colocalizes With Cdh1/2 At Sites Of Cell-Cell Contact Colocalizes With Ctnnb1 In The Endoplasmic Reticulum And The Proximity Of The Plasma Membrane Also Present In Azurophil Granules Of Neutrophils Colocalizes With Ubqln1 In The Cell Membrane And In Cytoplasmic Juxtanuclear Structures Called Aggresomes
Alternative Antibody Names	Anti-Presenilin-1 antibody Anti-Ps-1 antibody Anti-Protein S182 Cleaved Into - Presenilin-1 Ntf Subunit - Presenilin-1 Ctf Subunit - Presenilin-1 Ctf12 antibody Anti-Ps1-Ctf12 antibody Anti-PSEN1 antibody Anti-AD3 antibody Anti-PS1 antibody Anti-PSNL1 antibody

Information sourced from Uniprot.org

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