General Info
Host: | Rabbit |
Applications: | WB/IP |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-COMT (42-221) is suitable for use in Western Blot and Immunoprecipitation research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000IP 1:50-1:100 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | COMT |
Gene ID: | 1312 |
Uniprot ID: | COMT_HUMAN |
Immunogen Region: | 42-221 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-221 of human COMT (NP_009294.1). |
Immunogen Sequence: | VGDKKGKIVDAVIQEHQPSV LLELGAYCGYSAVRMARLLS PGARLITIEINPDCAAITQR MVDFAGVKDKVTLVVGASQD IIPQLKKKYDVDTLDMVFLD HWKDRYLPDTLLLEECGLLR KGTVLLADNVICPGAPDFLA HVRGSSCFECTHYQSFLEYR EVVDGLEKAIYKGPGSEAGP |
Description
Tissue Specificity | Brain, liver, placenta, lymphocytes and erythrocytes. |
Post Translational Modifications | The N-terminus is blocked. |
Function | Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. |
Protein Name | Catechol O-Methyltransferase |
Database Links | Reactome: R-HSA-156581Reactome: R-HSA-379397Reactome: R-HSA-379398Reactome: R-HSA-9679191 |
Cellular Localisation | Isoform Soluble: CytoplasmIsoform Membrane-Bound: Cell MembraneSingle-Pass Type Ii Membrane ProteinExtracellular Side |
Alternative Antibody Names | Anti-Catechol O-Methyltransferase antibodyAnti-COMT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance