General Info
Host: | Rat |
Applications: | FC |
Reactivity: | Mouse |
Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Short Description: | Rat monoclonal antibody anti-Integrin alpha-L is suitable for use in Flow Cytometry research applications. |
Clonality: | Monoclonal |
Clone ID: | FD441.8 |
Conjugation: | PE/Cyanine5.5 |
Isotype: | IgG2bk |
Formulation: | PBS with 0.05% Proclin300, 1% BSA |
Concentration: | 0.2 mg/mL |
Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Information
Gene Symbol: | Itgal |
Gene ID: | 16408 |
Uniprot ID: | ITAL_MOUSE |
Description
Tissue Specificity | Leukocytes. |
Post Translational Modifications | In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for the activation by some physiological agents. |
Function | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. |
Protein Name | Integrin Alpha-L Cd11 Antigen-Like Family Member A Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain Lfa-1a Leukocyte Function-Associated Molecule 1 Alpha Chain Lymphocyte Antigen 15 Ly-15 Cd Antigen Cd11a |
Database Links | Reactome: R-MMU-198933 Reactome: -MMU-202733 Reactome: -MMU-216083 Reactome: -MMU-6798695 |
Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-Integrin Alpha-L antibody Anti-Cd11 Antigen-Like Family Member A antibody Anti-Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain antibody Anti-Lfa-1a antibody Anti-Leukocyte Function-Associated Molecule 1 Alpha Chain antibody Anti-Lymphocyte Antigen 15 antibody Anti-Ly-15 antibody Anti-Cd Antigen Cd11a antibody Anti-Itgal antibody Anti-Lfa-1 antibody Anti-Ly-15 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance