Ambroxol [18683-91-5]
Cat# HY-B1039-100mg
Size : 100mg
Brand : MedChemExpress
Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.
For research use only. We do not sell to patients.
Ambroxol Chemical Structure
CAS No. : 18683-91-5
This product is a controlled substance and not for sale in your territory.
Based on 2 publication(s) in Google Scholar
Other Forms of Ambroxol:
- Ambroxol hydrochloride In-stock
- Ambroxol (acefylline) Get quote
Description |
Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2]. |
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In Vivo |
Ambroxol (NA-872; 1, 3, 4, 5 mM for 12 consecutive days in drinking water) results in increased brain glucocerebrosidase activity in wild-type mice, transgenic mice expressing the heterozygous L444P mutation in the murine glucocerebrosidase 1 gene, and transgenic mice overexpressing human α-synuclein[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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Molecular Weight |
378.10 |
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Formula |
C13H18Br2N2O |
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CAS No. |
18683-91-5 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O[C@H]1CC[C@H](NCC2=CC(Br)=CC(Br)=C2N)CC1 |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : ≥ 200 mg/mL (528.96 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.93% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.6448 mL | 13.2240 mL | 26.4480 mL | 66.1201 mL |
5 mM | 0.5290 mL | 2.6448 mL | 5.2896 mL | 13.2240 mL | |
10 mM | 0.2645 mL | 1.3224 mL | 2.6448 mL | 6.6120 mL | |
15 mM | 0.1763 mL | 0.8816 mL | 1.7632 mL | 4.4080 mL | |
20 mM | 0.1322 mL | 0.6612 mL | 1.3224 mL | 3.3060 mL | |
25 mM | 0.1058 mL | 0.5290 mL | 1.0579 mL | 2.6448 mL | |
30 mM | 0.0882 mL | 0.4408 mL | 0.8816 mL | 2.2040 mL | |
40 mM | 0.0661 mL | 0.3306 mL | 0.6612 mL | 1.6530 mL | |
50 mM | 0.0529 mL | 0.2645 mL | 0.5290 mL | 1.3224 mL | |
60 mM | 0.0441 mL | 0.2204 mL | 0.4408 mL | 1.1020 mL | |
80 mM | 0.0331 mL | 0.1653 mL | 0.3306 mL | 0.8265 mL | |
100 mM | 0.0264 mL | 0.1322 mL | 0.2645 mL | 0.6612 mL |
Ambroxol Related Classifications
- Metabolic Enzyme/Protease Autophagy
- Glucosidase Autophagy