TL1A antibody
Cat# orb613967-200ug
Size : 0.2mg
Brand : Biorbyt
TL1A antibody
Catalog Number: orb613967
| Catalog Number | orb613967 |
|---|---|
| Category | Antibodies |
| Description | Rat monoclonal antibody to TL1A |
| Species/Host | Rat |
| Clonality | Monoclonal |
| Clone Number | TAN2-2 |
| Tested applications | Blocking, FC, IF |
| Reactivity | Mouse |
| Isotype | IgG2a |
| Immunogen | This antibody was raised by immunising rats with a soluble recombinant TL1A (T77-L252):Fc protein. |
| Concentration | 1 mg/ml |
| Purity | Purified |
| Conjugation | Unconjugated |
| Target | TL1A |
| UniProt ID | Q5UBV8 |
| Storage | Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. |
| Buffer/Preservatives | PBS with 0.02% Proclin 300. |
| Alternative names | Tnfsf15; bM20K13.3 (tumor necrosis factor (ligand) |
| Note | For research use only |
| Application notes | This antibody has been used in FACS analyses to reveal the role of TL1A in humoral immune responses and its mechanism of action in the development of collagen-induced arthritis (Wang et al, 2013), and in immunofluorescence confocal microscopy to demonstrate how chronic DR3 signaling could promote pathogenesis in inflammatory bowel disease (Taraban et al, 2011). The therapeutic potential of this antagonistic anti-TL1A antibody in countering the DR3–TL1A pathway in the inflammatory joint disease has been confirmed in both of the murine adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) models (Bull et al, 2008). In addition, this antibody has been demonstrated to prevent chronic colitis and attenuate established colitis by down-regulation of both T-helper 1 and T-helper 17 activation (Takedatsu et al, 2008). |
| Expiration Date | 12 months from date of receipt. |