Spectinomycin (dihydrochloride) [21736-83-4]
Cat# HY-B0438-1ml
Size : 10mM/1mL
Brand : MedChemExpress
Spectinomycin dihydrochloride is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin dihydrochloride acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin dihydrochloride is also a noncompetitive inhibitor of td intron RNA with an Ki value of 7.2 mM-.
For research use only. We do not sell to patients.
Spectinomycin dihydrochloride Chemical Structure
CAS No. : 21736-83-4
This product is a controlled substance and not for sale in your territory.
Based on 3 publication(s) in Google Scholar
Other Forms of Spectinomycin dihydrochloride:
- Spectinomycin dihydrochloride pentahydrate In-stock
- Spectinomycin Get quote
Description |
Spectinomycin dihydrochloride is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin dihydrochloride acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin dihydrochloride is also a noncompetitive inhibitor of td intron RNA with an Ki value of 7.2 mM[1]-[5]. |
IC50 & Target |
bacterial ribosomal subunit[5] |
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In Vitro |
Spectinomycin dihydrochloride selectively inhibits protein synthesis in cells and in extracts of Escherichia coli: MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Spectinomycin dihydrochloride (20 mg/kg; i.m.; 20-100 mg/kg; 9 d) shows the safety in healthy chicks[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Molecular Weight |
405.27 |
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Formula |
C14H26Cl2N2O7 |
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CAS No. |
21736-83-4 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
CN[C@@H]([C@H]([C@@H](NC)[C@@H]1O)O)[C@]2(00)[C@]1(00)O[C@@](O[C@H](C)C3)(00)[C@](O)(C3=O)O2.Cl.Cl |
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Structure Classification |
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Initial Source |
bacterium Streptomyces spectabilis |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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Solvent & Solubility |
In Vitro:
H2O : ≥ 100 mg/mL (246.75 mM) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation |
Purity: 99.61% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O | 1 mM | 2.4675 mL | 12.3375 mL | 24.6749 mL | 61.6873 mL |
5 mM | 0.4935 mL | 2.4675 mL | 4.9350 mL | 12.3375 mL | |
10 mM | 0.2467 mL | 1.2337 mL | 2.4675 mL | 6.1687 mL | |
15 mM | 0.1645 mL | 0.8225 mL | 1.6450 mL | 4.1125 mL | |
20 mM | 0.1234 mL | 0.6169 mL | 1.2337 mL | 3.0844 mL | |
25 mM | 0.0987 mL | 0.4935 mL | 0.9870 mL | 2.4675 mL | |
30 mM | 0.0822 mL | 0.4112 mL | 0.8225 mL | 2.0562 mL | |
40 mM | 0.0617 mL | 0.3084 mL | 0.6169 mL | 1.5422 mL | |
50 mM | 0.0493 mL | 0.2467 mL | 0.4935 mL | 1.2337 mL | |
60 mM | 0.0411 mL | 0.2056 mL | 0.4112 mL | 1.0281 mL | |
80 mM | 0.0308 mL | 0.1542 mL | 0.3084 mL | 0.7711 mL | |
100 mM | 0.0247 mL | 0.1234 mL | 0.2467 mL | 0.6169 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Spectinomycin dihydrochloride Related Classifications
- Anti-infection
- Bacterial Antibiotic