Macrophage colony-stimulating factor (M-CSF), also known as CSF-1, is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. M-CSF enhances expression of differentiation antigens and stimulates chemotactic, phagocytic and the killing activities of monocytes. M-CSF also stimulates production of several cytokines, including GM- CSF, G-CSF and IL-6 by priming monocytes. It also stimulates production and secretion of IL-8 and reactive nitrogen intermediates. In addition to the stimulation of hematopoiesis, M-CSF also stimulates differentiation and proliferation of osteoclast progenitor cells and cytotrophoblasts.

Alternate Names - CSF1, CSF-1, MCSF, colony stimulating factor 1

Amino Acid Homology Across Species
Bos taurus (cattle) M-CSF – 100%
Bison bison bison (bison) M-CSF - 100%
Bos indicus (zebu) M-CSF - 100%
Bos mutus (wild yak) M-CSF - 100%
Bubalus bubalis (water buffalo) M-CSF – 99%
Capra hircus (goat) M-CSF – 99%
Ovis aries (sheep) M-CSF – 99%
Pantholops hodgsonii (chiru) M-CSF – 98%