Mouse EPO Polycolonal Antibody

Bulk quantities of Mouse EPO antibody are available.
Please for pricing.

Applications - ELISA and Western Blot

Mouse EPO ELISA Data

Reactivity - ELISA
Recombinant mouse EPO - Strong
Recombinant bovine EPO - Weak
Recombinant canine EPO - Weak
Recombinant equine EPO - Weak
Recombinant feline EPO - Weak
Recombinant rabbit EPO - Weak
Recombinant rat EPO - Moderate
Recombinant swine EPO - Weak

Mouse EPO Antibody Specifications

Quantity - 100 ug

Antibody Type - Polyclonal

Host - Rabbit

Immunogen - Recombinant Mouse EPO

Purification - Antigen-affinity

Label - None

EPO Background

Erythropoietin (EPO) is an essential hormone for red blood cell production. Without it, definitive erythropoiesis does not take place. Erythropoietin has its primary effect on red blood cell progenitors and precursors by promoting their survival through protecting these cells from apoptosis. It is the primary erythropoietic factor that cooperates with various other growth factors (e.g., IL-3, IL-6, glucocorticoids, and SCF) involved in the development of erythroid lineage from multipotent progenitors. Erythropoietin has a range of actions including vasoconstriction-dependent hypertension, stimulating angiogenesis, and inducing proliferation of smooth muscle fibers. It can increase iron absorption by suppressing the hormone hepcidin. EPO is highly glycosylated, with half-life in blood around five hours. The half-life of EPO may vary between endogenous and various recombinant versions. Additional glycosylation or other alterations of EPO via recombinant technology have led to increased stability in blood. EPO binds to the erythropoietin receptor on the red cell progenitor surface and activates a JAK2 signaling cascade. Erythropoietin receptor expression is found in a number of tissues, such as bone marrow and peripheral/central nervous tissue. In the bloodstream, red cells themselves do not express erythropoietin receptor, so cannot respond to EPO. However, indirect dependence of red cell longevity in the blood on plasma erythropoietin levels has been reported, a process termed neocytolysis.

Alternate Names - EPO, EP, MVCD2, erythropoietin, Erythropoietin, ECYT5, DBAL